H12/GNS/2/5

This page describes a signal of selection found in the Guinea An. gambiae populationusing the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 39,254,895 and 39,294,895. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 5 genes overlap the focal region: AGAP0068684 (CPR140 - cuticular protein RR-1 family 140), AGAP006869 (eupolytin), AGAP0068703, AGAP006871 (RpS4 - 40S ribosomal protein S4), AGAP006872 (NIMA (never in mitosis gene a)-related kinase).

The following 24 genes are within 50 kbp of the focal region: AGAP0068554 (CPR40 - cuticular protein RR-1 family 40), AGAP0068564 (CPR39 - cuticular protein RR-1 family 39), AGAP0068574 (CPR38 - cuticular protein RR-1 family 38), AGAP0068584 (CPR37 - cuticular protein RR-1 family 37), AGAP0068594 (CPR66 - cuticular protein RR-1 family 66), AGAP0068604 (CPR145 - cuticular protein RR-1 family 145), AGAP0068614 (CPR36 - cuticular protein RR-1 family 36), AGAP0068624 (CPR35 - cuticular protein RR-1 family 35), AGAP0068634 (CPR65 - cuticular protein RR-1 family 65), AGAP0068644 (CPR34 - cuticular protein RR-1 family 34), AGAP0068654 (CPR64 - cuticular protein RR-1 family 64), AGAP0068664 (CPR63 - cuticular protein RR-1 family 63), AGAP0068674 (CPR141 - cuticular protein RR-1 family 141), AGAP006873 (Ras-related protein Rab-8A), AGAP0068743 (Gr29 - gustatory receptor 29), AGAP0068753 (Gr30 - gustatory receptor 30), AGAP0068763 (Gr31 - gustatory receptor 31), AGAP0068773 (Gr32 - gustatory receptor 32), AGAP006878 (mitochondrial complex I protein Fmp36), AGAP006879 (F-type H -transporting ATPase subunit e), AGAP006880 (Protein LMBR1L), AGAP006881 (Polypeptide N-acetylgalactosaminyltransferase (Fragment)), AGAP006882, AGAP006883.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/CMS/2/5 IHS Cameroon An. gambiae 2L:39,274,895-39,314,895 137 95.6% nan
IHS/GNS/2/4 IHS Guinea An. gambiae 2L:39,274,895-39,314,895 119 96.8% nan
H12/CMS/2/4 H12 Cameroon An. gambiae 2L:39,274,895-39,314,895 112 98.7% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 47
    # data points      = 396
    # variables        = 4
    chi-square         = 0.071
    reduced chi-square = 0.000
    Akaike info crit   = -3410.701
    Bayesian info crit = -3394.776
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.10263598 +/- 0.009846 (9.59%) (init= 0.5)
    decay:       0.15000002 +/- 0.020738 (13.83%) (init= 0.5)
    skew:        0.01240441 +/- 0.137696 (1110.06%) (init= 0)
    baseline:    0.03205756 +/- 0.000701 (2.19%) (init= 0.03)
    ceiling:     1 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.696
    C(decay, baseline)           = -0.199

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 9
    # data points      = 395
    # variables        = 1
    chi-square         = 0.092
    reduced chi-square = 0.000
    Akaike info crit   = -3300.699
    Bayesian info crit = -3296.720
[[Variables]]
    c:   0.03367931 +/- 0.000770 (2.29%) (init= 0.03)

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