H12/GWA/2/1

This page describes a signal of selection found in the Guinea Bissau populationusing the H12 (Garud et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 31,954,895 and 31,994,895. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 2 genes overlap the focal region: AGAP006439 (fringe), AGAP006440 (IR136 - ionotropic receptor IR136).

Gene AGAP006441 (GTP cyclohydrolase I) is within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/GWA.UGS/2/1 XPEHH Guinea Bissau 2L:31,914,895-32,034,895 430 93.3% nan
XPEHH/GWA.BFS/2/2 XPEHH Guinea Bissau 2L:31,874,895-32,014,895 261 97.3% nan
XPEHH/GWA.BFM/2/3 XPEHH Guinea Bissau 2L:31,934,895-32,014,895 175 99.6% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 33
    # data points      = 393
    # variables        = 4
    chi-square         = 0.112
    reduced chi-square = 0.000
    Akaike info crit   = -3200.490
    Bayesian info crit = -3184.595
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.25298218 +/- 0.012112 (4.79%) (init= 0.5)
    decay:       0.15484055 +/- 0.010777 (6.96%) (init= 0.5)
    skew:        0.28590988 +/- 0.070170 (24.54%) (init= 0)
    baseline:    0.04377143 +/- 0.000892 (2.04%) (init= 0.03)
    ceiling:     1 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.687
    C(decay, baseline)           = -0.203
    C(decay, skew)               = -0.134

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 392
    # variables        = 1
    chi-square         = 0.294
    reduced chi-square = 0.001
    Akaike info crit   = -2818.473
    Bayesian info crit = -2814.502
[[Variables]]
    c:   0.04822766 +/- 0.001385 (2.87%) (init= 0.03)

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