XPEHH/GWA.BFM/2/3

This page describes a signal of selection found in the Guinea Bissau population when compared with the Burkina Faso An. coluzzii population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 31,934,895 and 32,014,895. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 2 genes overlap the focal region: AGAP006439 (fringe), AGAP006440 (IR136 - ionotropic receptor IR136).

The following 3 genes are within 50 kbp of the focal region: AGAP006438 (ribosomal biogenesis protein LAS1), AGAP006441 (GTP cyclohydrolase I), AGAP006442.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/GWA.UGS/2/1 XPEHH Guinea Bissau 2L:31,914,895-32,034,895 430 93.3% nan
H12/GWA/2/1 H12 Guinea Bissau 2L:31,954,895-31,994,895 382 99.2% nan
XPEHH/GWA.BFS/2/2 XPEHH Guinea Bissau 2L:31,874,895-32,014,895 261 97.3% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 38
    # data points      = 352
    # variables        = 4
    chi-square         = 59.583
    reduced chi-square = 0.171
    Akaike info crit   = -617.245
    Bayesian info crit = -601.791
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.76876293 +/- 0.123653 (6.99%) (init= 3)
    sigma:       0.16592867 +/- 0.018572 (11.19%) (init= 0.5)
    skew:        0.61699154 +/- 0.132779 (21.52%) (init= 0)
    baseline:    2.18757355 +/- 0.023142 (1.06%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, sigma)          = -0.526
    C(sigma, skew)               = -0.223
    C(amplitude, baseline)       = -0.162
    C(sigma, baseline)           = -0.125

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 351
    # variables        = 1
    chi-square         = 99.183
    reduced chi-square = 0.283
    Akaike info crit   = -441.600
    Bayesian info crit = -437.740
[[Variables]]
    c:   2.28628387 +/- 0.028413 (1.24%) (init= 1)

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