IHS/AOM/2/4

This page describes a signal of selection found in the Angola An. coluzzii populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 33,414,895 and 33,634,895. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 2 genes overlap the focal region: AGAP006514, AGAP006515 (Multiplexin transcript 1).

No genes are within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
H12/AOM/2/5 H12 Angola An. coluzzii 2L:33,434,895-33,514,895 290 96.7% nan
XPEHH/AOM.BFM/2/4 XPEHH Angola An. coluzzii 2L:33,454,895-33,594,895 173 98.8% nan
XPEHH/AOM.GWA/2/3 XPEHH Angola An. coluzzii 2L:33,434,895-33,594,895 161 92.9% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 28
    # data points      = 335
    # variables        = 4
    chi-square         = 89.153
    reduced chi-square = 0.269
    Akaike info crit   = -435.466
    Bayesian info crit = -420.210
[[Variables]]
    center:      0 (fixed)
    amplitude:   2.55833174 +/- 0.215683 (8.43%) (init= 3)
    decay:       0.51889341 +/- 0.073239 (14.11%) (init= 0.5)
    skew:       -0.90963550 +/- 0.142560 (15.67%) (init= 0)
    baseline:    2.56715306 +/- 0.034696 (1.35%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.585
    C(decay, baseline)           = -0.430
    C(decay, skew)               =  0.387

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 334
    # variables        = 1
    chi-square         = 144.222
    reduced chi-square = 0.433
    Akaike info crit   = -278.489
    Bayesian info crit = -274.678
[[Variables]]
    c:   2.74027063 +/- 0.036008 (1.31%) (init= 1)

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