XPEHH/AOM.GWA/2/3

This page describes a signal of selection found in the Angola An. coluzzii population when compared with the Guinea Bissau population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 33,434,895 and 33,594,895. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

Gene AGAP006514 overlaps the focal region.

Gene AGAP006515 (Multiplexin transcript 1) is within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
H12/AOM/2/5 H12 Angola An. coluzzii 2L:33,434,895-33,514,895 290 96.7% nan
XPEHH/AOM.BFM/2/4 XPEHH Angola An. coluzzii 2L:33,454,895-33,594,895 173 98.8% nan
IHS/AOM/2/4 IHS Angola An. coluzzii 2L:33,414,895-33,634,895 156 99.9% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 38
    # data points      = 183
    # variables        = 4
    chi-square         = 36.766
    reduced chi-square = 0.205
    Akaike info crit   = -285.700
    Bayesian info crit = -272.862
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.58325070 +/- 0.102600 (6.48%) (init= 3)
    sigma:       0.53949479 +/- 0.058312 (10.81%) (init= 0.5)
    skew:       -0.99999999 +/- 0.073252 (7.33%) (init= 0)
    baseline:    1.45278437 +/- 0.042976 (2.96%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(sigma, skew)               = -0.487
    C(amplitude, sigma)          = -0.345
    C(amplitude, baseline)       = -0.335
    C(sigma, baseline)           = -0.312

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 182
    # variables        = 1
    chi-square         = 91.015
    reduced chi-square = 0.503
    Akaike info crit   = -124.123
    Bayesian info crit = -120.919
[[Variables]]
    c:   1.81513421 +/- 0.052563 (2.90%) (init= 1)

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