IHS/BFM/2/1

This page describes a signal of selection found in the Burkina Faso An. coluzzii populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 28,700,000 and 29,020,000. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 11 genes overlap the focal region: AGAP002886 (GPRNNA2 - putative GPCR class a orphan receptor 2), AGAP002888 (GPRNNA3 - putative GPCR class a orphan receptor 3), AGAP013540, AGAP0028891 (NADH dehydrogenase (ubiquinone) 1 subcomplex unknown 2), AGAP002890 (Lipid storage droplets surface-binding protein 1), AGAP002891 (GPRMGL4 - putative metabotropic glutamate receptor 4), AGAP002892 (heterogeneous nuclear ribonucleoprotein F/H), AGAP002893 (mRpS23 - 28S ribosomal protein S23, mitochondrial), AGAP0028941 (CYP6Z4 - cytochrome P450), AGAP002895 (mRNA (2’-O-methyladenosine-N6-)-methyltransferase), AGAP002896 (RNA-binding protein Nova).

The following 5 genes are within 50 kbp of the focal region: AGAP002881 (GPRNPR1 - putative neuropeptide receptor 1), AGAP0028831, AGAP013115, AGAP002884 (V-type H -transporting ATPase subunit B), AGAP002885.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/UGS/2/1 IHS Uganda An. gambiae 2R:28,280,000-28,700,000 1,661 100.0% Cyp6p
IHS/GNS/2/1 IHS Guinea An. gambiae 2R:28,440,000-28,700,000 1,134 99.8% Cyp6p
XPEHH/UGS.CMS/2/1 XPEHH Uganda An. gambiae 2R:28,860,000-28,980,000 645 99.7% nan
XPEHH/CMS.GAS/2/3 XPEHH Cameroon An. gambiae 2R:28,560,000-28,800,000 191 100.0% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 48
    # data points      = 683
    # variables        = 4
    chi-square         = 238.727
    reduced chi-square = 0.352
    Akaike info crit   = -709.951
    Bayesian info crit = -691.845
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.76358531 +/- 0.069413 (3.94%) (init= 3)
    sigma:       1.13907486 +/- 0.064215 (5.64%) (init= 0.5)
    skew:        0.99999793 +/- 0.062820 (6.28%) (init= 0)
    baseline:    3.82953914 +/- 0.032501 (0.85%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(sigma, baseline)           = -0.463
    C(sigma, skew)               = -0.427
    C(amplitude, baseline)       = -0.341
    C(amplitude, sigma)          = -0.251

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 13
    # data points      = 682
    # variables        = 1
    chi-square         = 477.234
    reduced chi-square = 0.701
    Akaike info crit   = -241.489
    Bayesian info crit = -236.964
[[Variables]]
    c:   4.25640168 +/- 0.032055 (0.75%) (init= 1)

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