IHS/BFS/2/6

This page describes a signal of selection found in the Burkina Faso An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 46,034,895 and 46,214,895. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 26 genes overlap the focal region: AGAP007358 (cellular retinaldehyde binding protein), AGAP007359, AGAP007361 (translocation protein SEC63), AGAP007362 (SH3 domain-binding glutamic acid-rich-like protein 3), AGAP007363, AGAP007364, AGAP007365, AGAP007366, AGAP007367 (solute carrier family 6 (neurotransmitter transporter, dopamine) member 3), AGAP007368, AGAP007369 (Ras-related protein Rap-1b precursor), AGAP007370, AGAP007371, AGAP007372, AGAP007373 (Tetraspanin), AGAP007374 (glucuronosyltransferase), AGAP007375, AGAP013291 (Trafficking protein particle complex 3), AGAP007376 (nuclear transcription factor Y, alpha), AGAP007377, AGAP007378 (N-acetyltransferase 9), AGAP0135441 (L-gulonate 3-dehydrogenase), AGAP007379 (ArfGAP with dual PH domains 2), AGAP007380 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex 11), AGAP007381, AGAP007382 (Fem-1 homolog b).

The following 13 genes are within 50 kbp of the focal region: AGAP007348 (coiled-coil domain-containing protein 102A), AGAP007349, AGAP007353 (phosphatidylinositol transfer protein SEC14), AGAP007354 (phosphatidylinositol transfer protein SEC14), AGAP007355 (cellular retinaldehyde binding protein), AGAP007356 (cellular retinaldehyde binding protein), AGAP007357 (retinaldehyde-binding protein 1-like protein 1), AGAP007383, AGAP007384, AGAP007385 (LYSC4 - C-type lysozyme), AGAP007386 (LYSC7 - C-type lysozyme), AGAP007387 (DNA methyltransferase 1-associated protein 1), AGAP007388 (midasin).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/CMS/2/7 IHS Cameroon An. gambiae 2L:46,054,895-46,094,895 98 77.4% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 28
    # data points      = 646
    # variables        = 4
    chi-square         = 128.543
    reduced chi-square = 0.200
    Akaike info crit   = -1034.990
    Bayesian info crit = -1017.107
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.71009409 +/- 0.130024 (7.60%) (init= 3)
    decay:       0.45634361 +/- 0.055327 (12.12%) (init= 0.5)
    skew:        0.44358587 +/- 0.115898 (26.13%) (init= 0)
    baseline:    1.78814605 +/- 0.020610 (1.15%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.640
    C(decay, baseline)           = -0.383
    C(decay, skew)               = -0.172

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 645
    # variables        = 1
    chi-square         = 182.161
    reduced chi-square = 0.283
    Akaike info crit   = -813.512
    Bayesian info crit = -809.043
[[Variables]]
    c:   1.90660454 +/- 0.020941 (1.10%) (init= 1)

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