IHS/CMS/X/1

This page describes a signal of selection found in the Cameroon An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm X between positions 15,520,000 and 15,560,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 4 genes overlap the focal region: AGAP000840 (amiloride-sensitive sodium channel, other), AGAP000841 (Ras-related protein Rab-40), AGAP013101, AGAP000842 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1).

The following 3 genes are within 50 kbp of the focal region: AGAP013506, AGAP000843 (cardiolipin synthase), AGAP000844 (Progestin and adipoQ receptor family member 4).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/GNS/X/1 IHS Guinea An. gambiae X:15,240,000-15,780,000 553 99.3% Cyp9k1
IHS/BFM/X/1 IHS Burkina Faso An. coluzzii X:14,760,000-15,620,000 501 100.0% Cyp9k1

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 42
    # data points      = 317
    # variables        = 4
    chi-square         = 35.679
    reduced chi-square = 0.114
    Akaike info crit   = -684.432
    Bayesian info crit = -669.396
[[Variables]]
    center:      0 (fixed)
    amplitude:   2.92560185 +/- 0.230581 (7.88%) (init= 3)
    decay:       0.15000000 +/- 0.003695 (2.46%) (init= 0.5)
    skew:        0.31768984 +/- 0.132781 (41.80%) (init= 0)
    baseline:    1.63467441 +/- 0.019747 (1.21%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          =  0.657
    C(decay, baseline)           =  0.194

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 316
    # variables        = 1
    chi-square         = 60.234
    reduced chi-square = 0.191
    Akaike info crit   = -521.770
    Bayesian info crit = -518.014
[[Variables]]
    c:   1.69250264 +/- 0.024599 (1.45%) (init= 1)

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