IHS/GNS/2/5

This page describes a signal of selection found in the Guinea An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 42,274,895 and 42,414,895. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 6 genes overlap the focal region: AGAP007083, AGAP007084, AGAP007085, AGAP0070862 (Sodium channel protein), AGAP007087 (RpL41 - 60s ribosomal protein L41), AGAP007088 (peptidyl-prolyl cis-trans isomerase B (cyclophilin B)).

The following 6 genes are within 50 kbp of the focal region: AGAP007079, AGAP007080 (hexosaminidase), AGAP007081, AGAP0070821 (NADH dehydrogenase (ubiquinone) Fe-S protein 4), AGAP007089, AGAP007090.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/BFS/2/7 IHS Burkina Faso An. gambiae 2L:42,314,895-42,454,895 222 95.5% nan
IHS/CMS/2/6 IHS Cameroon An. gambiae 2L:42,394,895-42,434,895 90 77.8% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 38
    # data points      = 572
    # variables        = 4
    chi-square         = 57.170
    reduced chi-square = 0.101
    Akaike info crit   = -1309.379
    Bayesian info crit = -1291.982
[[Variables]]
    center:      0 (fixed)
    amplitude:   0.82158270 +/- 0.084153 (10.24%) (init= 3)
    sigma:       0.24248233 +/- 0.032627 (13.46%) (init= 0.5)
    skew:        0.30435119 +/- 0.159959 (52.56%) (init= 0)
    baseline:    1.88617587 +/- 0.013938 (0.74%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, sigma)          = -0.513
    C(sigma, baseline)           = -0.177
    C(amplitude, baseline)       = -0.124

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 571
    # variables        = 1
    chi-square         = 68.297
    reduced chi-square = 0.120
    Akaike info crit   = -1210.532
    Bayesian info crit = -1206.185
[[Variables]]
    c:   1.92346258 +/- 0.014485 (0.75%) (init= 1)

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