IHS/GNS/3/2

This page describes a signal of selection found in the Guinea An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 4,400,000 and 4,960,000. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 37 genes overlap the focal region: AGAP008025 (Homeobox protein engrailed-like), AGAP013728, AGAP008026 (enhancer of polycomb-like protein), AGAP008027 (Slowmo), AGAP008028 (voltage-dependent calcium channel beta, invertebrate), AGAP028427, AGAP008033, AGAP013760, AGAP008034 (solute carrier family 39 (zinc transporter), member 7), AGAP008035, AGAP008036, AGAP008037 (KDEL (Lys-Asp-Glu-Leu) containing 1, isoform CRA_a), AGAP008039 (protein kinase A), AGAP008040, AGAP008041 (RING finger protein 121), AGAP0080421 (pyridine nucleotide-disulfide oxidoreductase domain 1), AGAP008043 (mRpS18B - 28S ribosomal protein S18B, mitochondrial), AGAP0080441 (programmed cell death 8 (apoptosis-inducing factor)), AGAP008045 (transcription initiation factor TFIID subunit 13), AGAP013736, AGAP008046 (protein kinase C and casein kinase substrate in neurons 2 protein), AGAP013713, AGAP008047 (integrator complex subunit 1), AGAP008048, AGAP008049 (cell division cycle 123 homolog), AGAP008050 (phosphorylated adapter RNA export protein), AGAP008051 (SAP1 - sensory appendage protein 1), AGAP008052 (SAP2 - sensory appendage protein 2), AGAP008053 (sphingomyelin phosphodiesterase 2), AGAP008054 (SAP3 - sensory appendage protein 3), AGAP008055 (CSP3 - chemosensory protein 3), AGAP008056, AGAP029127 (CSP5 - chemosensory protein 5), AGAP008059 (CSP1 - chemosensory protein 1), AGAP008060 (IDGF2 - imaginal disc growth factor 2), AGAP008061 (IDGF4 - imaginal disc growth factor 4), AGAP008062 (CSP4 - chemosensory protein 4).

The following 5 genes are within 50 kbp of the focal region: AGAP008023 (en - segmentation polarity homeobox protein engrailed), AGAP008063 (exosome complex component CSL4), AGAP008064 (uroporphyrinogen-III synthase), AGAP008065, AGAP013757.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/BFS/3/2 IHS Burkina Faso An. gambiae 3R:4,340,000-4,740,000 504 95.7% nan
H12/GNS/3/2 H12 Guinea An. gambiae 3R:4,600,000-5,060,000 253 77.2% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 28
    # data points      = 664
    # variables        = 4
    chi-square         = 121.595
    reduced chi-square = 0.184
    Akaike info crit   = -1119.195
    Bayesian info crit = -1101.202
[[Variables]]
    center:      0 (fixed)
    amplitude:   2.04845614 +/- 0.085612 (4.18%) (init= 3)
    decay:       1.04495854 +/- 0.080020 (7.66%) (init= 0.5)
    skew:       -0.75061850 +/- 0.067250 (8.96%) (init= 0)
    baseline:    1.83033325 +/- 0.024743 (1.35%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, baseline)           = -0.573
    C(amplitude, decay)          = -0.521
    C(decay, skew)               =  0.281

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 663
    # variables        = 1
    chi-square         = 262.949
    reduced chi-square = 0.397
    Akaike info crit   = -611.151
    Bayesian info crit = -606.655
[[Variables]]
    c:   2.14156683 +/- 0.024476 (1.14%) (init= 1)

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