IHS/UGS/2/5

This page describes a signal of selection found in the Uganda An. gambiae populationusing the IHS (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 40,160,000 and 40,200,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 2 genes overlap the focal region: AGAP0035781 (aldehyde dehydrogenase (NAD )), AGAP003579 (cadherin-87A).

No genes are within 50 kbp of the focal region.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/CMS/2/2 IHS Cameroon An. gambiae 2R:40,060,000-40,780,000 643 100.0% nan
IHS/GNS/2/3 IHS Guinea An. gambiae 2R:40,200,000-40,420,000 450 99.0% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 65
    # data points      = 572
    # variables        = 4
    chi-square         = 110.807
    reduced chi-square = 0.195
    Akaike info crit   = -930.853
    Bayesian info crit = -913.457
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.37530358 +/- 0.138506 (10.07%) (init= 3)
    decay:       0.35094332 +/- 0.060638 (17.28%) (init= 0.5)
    skew:       -0.99999999 +/- 0.059371 (5.94%) (init= 0)
    baseline:    2.35799341 +/- 0.021225 (0.90%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, decay)          = -0.595
    C(decay, skew)               =  0.433
    C(decay, baseline)           = -0.319

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 571
    # variables        = 1
    chi-square         = 140.592
    reduced chi-square = 0.247
    Akaike info crit   = -798.270
    Bayesian info crit = -793.923
[[Variables]]
    c:   2.45453942 +/- 0.020783 (0.85%) (init= 1)

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