XPEHH/AOM.BFM/2/5

This page describes a signal of selection found in the Angola An. coluzzii population when compared with the Burkina Faso An. coluzzii population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 8,140,000 and 8,240,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 4 genes overlap the focal region: AGAP001679, AGAP001680, AGAP001681 (ubiquitin conjugation factor E4 A), AGAP001682 (Mitochondrial inner membrane protease subunit 1).

The following 3 genes are within 50 kbp of the focal region: AGAP001678, AGAP013310, AGAP001683 (calcium/calmodulin-dependent serine protein kinase).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/AOM/2/2 IHS Angola An. coluzzii 2R:8,160,000-8,280,000 230 99.7% nan
XPEHH/AOM.GWA/2/4 XPEHH Angola An. coluzzii 2R:8,120,000-8,320,000 107 78.7% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 62
    # data points      = 217
    # variables        = 4
    chi-square         = 29.301
    reduced chi-square = 0.138
    Akaike info crit   = -426.492
    Bayesian info crit = -412.972
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.29288586 +/- 0.085702 (6.63%) (init= 3)
    sigma:       0.26378668 +/- 0.029455 (11.17%) (init= 0.5)
    skew:       -0.99999997 +/- 0.136206 (13.62%) (init= 0)
    baseline:    1.40347689 +/- 0.030670 (2.19%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(sigma, skew)               =  0.612
    C(amplitude, sigma)          = -0.382
    C(amplitude, baseline)       = -0.293
    C(sigma, baseline)           = -0.249

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 216
    # variables        = 1
    chi-square         = 64.696
    reduced chi-square = 0.301
    Akaike info crit   = -258.406
    Bayesian info crit = -255.030
[[Variables]]
    c:   1.63883778 +/- 0.037324 (2.28%) (init= 1)

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