XPEHH/AOM.GWA/2/4

This page describes a signal of selection found in the Angola An. coluzzii population when compared with the Guinea Bissau population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 8,120,000 and 8,320,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 6 genes overlap the focal region: AGAP013310, AGAP001679, AGAP001680, AGAP001681 (ubiquitin conjugation factor E4 A), AGAP001682 (Mitochondrial inner membrane protease subunit 1), AGAP001683 (calcium/calmodulin-dependent serine protein kinase).

The following 2 genes are within 50 kbp of the focal region: AGAP001678, AGAP001684 (Alkaline phosphatase).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
H12/AOM/2/1 H12 Angola An. coluzzii 2R:8,280,000-8,340,000 479 97.0% nan
IHS/AOM/2/2 IHS Angola An. coluzzii 2R:8,160,000-8,280,000 230 99.7% nan
XPEHH/AOM.BFM/2/5 XPEHH Angola An. coluzzii 2R:8,140,000-8,240,000 168 89.0% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 48
    # data points      = 161
    # variables        = 4
    chi-square         = 14.696
    reduced chi-square = 0.094
    Akaike info crit   = -377.407
    Bayesian info crit = -365.081
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.04413636 +/- 0.089480 (8.57%) (init= 3)
    sigma:       0.23229447 +/- 0.036642 (15.77%) (init= 0.5)
    skew:       -0.58900568 +/- 0.189400 (32.16%) (init= 0)
    baseline:    1.18031973 +/- 0.027791 (2.35%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(sigma, skew)               =  0.590
    C(amplitude, sigma)          = -0.471
    C(amplitude, baseline)       = -0.256
    C(sigma, baseline)           = -0.192
    C(amplitude, skew)           = -0.165

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 9
    # data points      = 160
    # variables        = 1
    chi-square         = 29.175
    reduced chi-square = 0.183
    Akaike info crit   = -270.299
    Bayesian info crit = -267.224
[[Variables]]
    c:   1.32914129 +/- 0.033862 (2.55%) (init= 1)

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