XPEHH/BFM.BFS/X/1

This page describes a signal of selection found in the Burkina Faso An. coluzzii population when compared with the Burkina Faso An. gambiae population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm X between positions 15,580,000 and 15,800,000. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 11 genes overlap the focal region: AGAP000847 (CDC-like kinase), AGAP000848, AGAP000849 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex 1), AGAP000850, AGAP0008511 (cytochrome c oxidase subunit 6a, mitochrondrial), AGAP000852 (Small ubiquitin-related modifier), AGAP000853 (gamma-glutamyltranspeptidase), AGAP000854, AGAP000855, AGAP0008561 (tRNA-dihydrouridine synthase 2), AGAP000857 (mRpL3 - 39S ribosomal protein L3, mitochondrial).

The following 12 genes are within 50 kbp of the focal region: AGAP000840 (amiloride-sensitive sodium channel, other), AGAP000841 (Ras-related protein Rab-40), AGAP013101, AGAP000842 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1), AGAP000843 (cardiolipin synthase), AGAP000844 (Progestin and adipoQ receptor family member 4), AGAP013097, AGAP012991 (Fascin), AGAP000858, AGAP000859, AGAP013522, AGAP000860 (Protein tweety homolog).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/GNS/X/1 IHS Guinea An. gambiae X:15,240,000-15,780,000 553 99.3% Cyp9k1
IHS/BFM/X/1 IHS Burkina Faso An. coluzzii X:14,760,000-15,620,000 501 100.0% Cyp9k1

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 58
    # data points      = 414
    # variables        = 4
    chi-square         = 212.959
    reduced chi-square = 0.519
    Akaike info crit   = -267.213
    Bayesian info crit = -251.109
[[Variables]]
    center:      0 (fixed)
    amplitude:   6.95495305 +/- 0.178542 (2.57%) (init= 3)
    decay:       0.85876760 +/- 0.039526 (4.60%) (init= 0.5)
    skew:        0.34935012 +/- 0.037781 (10.81%) (init= 0)
    baseline:    1.47798949 +/- 0.054542 (3.69%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, baseline)           = -0.627
    C(amplitude, decay)          = -0.495

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 413
    # variables        = 1
    chi-square         = 1225.392
    reduced chi-square = 2.974
    Akaike info crit   = 451.166
    Bayesian info crit = 455.189
[[Variables]]
    c:   2.50549839 +/- 0.084861 (3.39%) (init= 1)

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