XPEHH/CMS.GWA/2/3

This page describes a signal of selection found in the Cameroon An. gambiae population when compared with the Guinea Bissau population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 40,680,000 and 40,760,000. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 8 genes overlap the focal region: AGAP029110, AGAP003626, AGAP013221, AGAP012946, AGAP003627, AGAP003629, AGAP003630, AGAP003631 (GPRGRP2 - putative gastrin/bombesin receptor 2).

The following 5 genes are within 50 kbp of the focal region: AGAP003624, AGAP003632 (U3 small nucleolar RNA-associated protein 14), AGAP003633, AGAP003635, AGAP0036361 (inositol oxygenase).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/CMS/2/2 IHS Cameroon An. gambiae 2R:40,060,000-40,780,000 643 100.0% nan
H12/CMS/2/3 H12 Cameroon An. gambiae 2R:40,300,000-40,740,000 501 98.7% nan
H12/BFS/2/4 H12 Burkina Faso An. gambiae 2R:40,640,000-41,060,000 384 95.9% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 277
    # data points      = 434
    # variables        = 4
    chi-square         = 103.334
    reduced chi-square = 0.240
    Akaike info crit   = -614.824
    Bayesian info crit = -598.532
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.02939858 +/- 0.092249 (8.96%) (init= 3)
    decay:       2.99994449 +/- 0.604325 (20.14%) (init= 0.5)
    skew:       -0.99999980 +/- 0.141134 (14.11%) (init= 0)
    baseline:    1.37600164 +/- 0.083851 (6.09%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, baseline)           = -0.836
    C(amplitude, baseline)       = -0.732
    C(amplitude, decay)          =  0.357
    C(decay, skew)               = -0.307
    C(amplitude, skew)           = -0.267
    C(skew, baseline)            =  0.263

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 433
    # variables        = 1
    chi-square         = 131.503
    reduced chi-square = 0.304
    Akaike info crit   = -514.008
    Bayesian info crit = -509.938
[[Variables]]
    c:   1.84882268 +/- 0.026514 (1.43%) (init= 1)

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