XPEHH/GAS.AOM/2/1

This page describes a signal of selection found in the Gabon An. gambiae population when compared with the Angola An. coluzzii population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 14,654,895 and 14,834,895. The evidence supporting this signal is weak (\Delta_{i} < 50 on one or both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 17 genes overlap the focal region: AGAP005364 (protein BAT5), AGAP005365 (ribosome biogenesis protein BRX1), AGAP005366 (serine/arginine repetitive matrix protein 1), AGAP005368, AGAP005369, AGAP005370 (COEBE4C - carboxylesterase beta esterase), AGAP0053711 (COEBE2C - carboxylesterase beta esterase), AGAP0053721 (COEBE3C - carboxylesterase beta esterase), AGAP0053731 (COEBE1C - carboxylesterase beta esterase), AGAP005374, AGAP005375 (nonsense-mediated mRNA decay protein), AGAP005376, AGAP005377, AGAP005378, AGAP005379, AGAP005380, AGAP005381 (hexosaminidase).

The following 15 genes are within 50 kbp of the focal region: AGAP005356 (predicted G-protein coupled receptor GPCR), AGAP005359 (F-box and WD-40 domain protein 7), AGAP005360 (PQ loop repeat-containing protein 3), AGAP005361, AGAP005362 (NF-X1-type zinc finger protein NFXL1), AGAP005363, AGAP005382 (transcription initiation factor TFIIE subunit beta), AGAP005383 (cellular retinaldehyde binding protein), AGAP005384 (phosphatidylinositol transfer protein SEC14), AGAP005385 (phosphatidylinositol transfer protein SEC14), AGAP005386, AGAP005387 (cellular retinaldehyde binding protein), AGAP005388 (cellular retinaldehyde binding protein), AGAP005389, AGAP005390.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
H12/GAS/2/3 H12 Gabon An. gambiae 2L:14,694,895-14,814,895 121 98.8% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 63
    # data points      = 298
    # variables        = 4
    chi-square         = 77.494
    reduced chi-square = 0.264
    Akaike info crit   = -393.374
    Bayesian info crit = -378.586
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.19477016 +/- 0.088756 (7.43%) (init= 3)
    sigma:       2.35799535 +/- 0.235591 (9.99%) (init= 0.5)
    skew:       -1          +/- 0.005332 (0.53%) (init= 0)
    baseline:    1.15691003 +/- 0.074084 (6.40%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, baseline)       = -0.774
    C(sigma, baseline)           = -0.560
    C(sigma, skew)               = -0.451
    C(amplitude, sigma)          =  0.151

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 297
    # variables        = 1
    chi-square         = 123.264
    reduced chi-square = 0.416
    Akaike info crit   = -259.184
    Bayesian info crit = -255.490
[[Variables]]
    c:   1.85404759 +/- 0.037444 (2.02%) (init= 1)

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