XPEHH/GAS.BFS/3/2

This page describes a signal of selection found in the Gabon An. gambiae population when compared with the Burkina Faso An. gambiae population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 3R between positions 520,000 and 680,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 6 genes overlap the focal region: AGAP007771, AGAP007772, AGAP007773, AGAP007774, AGAP007775 (ATP-dependent DNA helicase PIF1), AGAP007776.

The following 8 genes are within 50 kbp of the focal region: AGAP007761 (Complement control protein), AGAP007763, AGAP007764, AGAP007765, AGAP007766 (jumonji domain containing 7), AGAP007767, AGAP007768 (mitochondrial cytochrome c oxidase subunit VIC), AGAP007769 (Katanin-60).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/GWA/3/1 IHS Guinea Bissau 3R:660,000-700,000 363 100.0% nan
XPEHH/GWA.UGS/3/1 XPEHH Guinea Bissau 3R:660,000-700,000 346 100.0% nan
XPEHH/GWA.BFS/3/1 XPEHH Guinea Bissau 3R:660,000-700,000 313 99.9% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 38
    # data points      = 291
    # variables        = 4
    chi-square         = 127.758
    reduced chi-square = 0.445
    Akaike info crit   = -231.548
    Bayesian info crit = -216.855
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.91885001 +/- 0.128862 (6.72%) (init= 3)
    sigma:       0.35055832 +/- 0.032731 (9.34%) (init= 0.5)
    skew:        0.82102616 +/- 0.108188 (13.18%) (init= 0)
    baseline:    2.06205726 +/- 0.047214 (2.29%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, sigma)          = -0.405
    C(amplitude, baseline)       = -0.319
    C(sigma, baseline)           = -0.292

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 290
    # variables        = 1
    chi-square         = 239.458
    reduced chi-square = 0.829
    Akaike info crit   = -53.536
    Bayesian info crit = -49.866
[[Variables]]
    c:   2.42060476 +/- 0.053451 (2.21%) (init= 1)

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