XPEHH/GAS.BFS/X/1

This page describes a signal of selection found in the Gabon An. gambiae population when compared with the Burkina Faso An. gambiae population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm X between positions 14,040,000 and 14,400,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 12 genes overlap the focal region: AGAP0007801 (Yippee-like 5), AGAP000781 (mitochondrial import inner membrane translocase subunit Tim9), AGAP000782, AGAP000783, AGAP000784 (abhydrolase domain containing 4), AGAP000785 (Synaptic vesicle protein), AGAP000786, AGAP000787 (E3 ubiquitin-protein ligase NEDD4), AGAP000788, AGAP013147, AGAP000789, AGAP000790.

The following 5 genes are within 50 kbp of the focal region: AGAP000791 (Tango10), AGAP000792 (Adenosylhomocysteinase), AGAP000793, AGAP0007941 (NADH dehydrogenase (ubiquinone) Fe-S protein 2), AGAP013289.

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
H12/GAS/X/1 H12 Gabon An. gambiae X:13,920,000-14,440,000 243 100.0% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_exponential_peak)
[[Fit Statistics]]
    # function evals   = 67
    # data points      = 477
    # variables        = 4
    chi-square         = 139.154
    reduced chi-square = 0.294
    Akaike info crit   = -579.632
    Bayesian info crit = -562.962
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.59608159 +/- 0.095935 (6.01%) (init= 3)
    decay:       2.99999930 +/- 0.908656 (30.29%) (init= 0.5)
    skew:        0.91481929 +/- 0.118422 (12.94%) (init= 0)
    baseline:    1.45568187 +/- 0.093149 (6.40%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(decay, baseline)           =  0.860
    C(amplitude, baseline)       = -0.711
    C(decay, skew)               =  0.597
    C(skew, baseline)            =  0.496
    C(amplitude, skew)           = -0.412
    C(amplitude, decay)          = -0.380

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 476
    # variables        = 1
    chi-square         = 237.347
    reduced chi-square = 0.500
    Akaike info crit   = -329.246
    Bayesian info crit = -325.080
[[Variables]]
    c:   2.20281308 +/- 0.032399 (1.47%) (init= 1)

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