XPEHH/UGS.BFS/2/4

This page describes a signal of selection found in the Uganda An. gambiae population when compared with the Burkina Faso An. gambiae population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2L between positions 14,374,895 and 14,554,895. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 9 genes overlap the focal region: AGAP005347 (alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase), AGAP005348, AGAP005349, AGAP005350, AGAP005351 (DEAD box polypeptide 5), AGAP005352 (tyrosine-protein phosphatase non-receptor type 1), AGAP005353 (biogenesis of lysosome-related organelles complex 1 subunit 2), AGAP005354, AGAP005355.

The following 3 genes are within 50 kbp of the focal region: AGAP005345, AGAP005346, AGAP005356 (predicted G-protein coupled receptor GPCR).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/UGS.CMS/2/4 XPEHH Uganda An. gambiae 2L:14,374,895-14,554,895 92 91.4% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 33
    # data points      = 569
    # variables        = 4
    chi-square         = 185.509
    reduced chi-square = 0.328
    Akaike info crit   = -629.723
    Bayesian info crit = -612.347
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.48577310 +/- 0.124166 (8.36%) (init= 3)
    sigma:       0.28782456 +/- 0.029290 (10.18%) (init= 0.5)
    skew:        0.16571507 +/- 0.115266 (69.56%) (init= 0)
    baseline:    1.16421414 +/- 0.026259 (2.26%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, sigma)          = -0.532
    C(sigma, baseline)           = -0.234
    C(amplitude, baseline)       = -0.154

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 9
    # data points      = 568
    # variables        = 1
    chi-square         = 244.294
    reduced chi-square = 0.431
    Akaike info crit   = -477.250
    Bayesian info crit = -472.908
[[Variables]]
    c:   1.28186027 +/- 0.027540 (2.15%) (init= 1)

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