XPEHH/AOM.BFM/2/3

This page describes a signal of selection found in the Angola An. coluzzii population when compared with the Burkina Faso An. coluzzii population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm 2R between positions 28,000,000 and 28,060,000. The evidence supporting this signal is strong (\Delta_{i} >= 100 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 4 genes overlap the focal region: AGAP002824 (GPRTAK1 - putative tachykinin receptor 1), AGAP0028251 (PPO1 - prophenoloxidase 1), AGAP002826, AGAP002828.

The following 13 genes are within 50 kbp of the focal region: AGAP0028161 (ERO1-like protein alpha), AGAP002817, AGAP002818, AGAP002819, AGAP002820, AGAP002821, AGAP002822, AGAP002823 (Med7 - Mediator of RNA polymerase II transcription subunit 7), AGAP002829 (SPN-E - ATP-dependent RNA helicase spindle-E), AGAP0028301 (C-1-tetrahydrofolate synthase, mitochondrial precursor), AGAP002831 (ribosomal RNA small subunit methyltransferase H), AGAP013130, AGAP002832 (protein-tyrosine phosphatase).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
XPEHH/UGS.BFS/2/1 XPEHH Uganda An. gambiae 2R:27,980,000-28,280,000 753 99.9% nan
H12/AOM/2/2 H12 Angola An. coluzzii 2R:28,040,000-28,080,000 478 100.0% nan
IHS/AOM/2/1 IHS Angola An. coluzzii 2R:27,980,000-28,040,000 324 100.0% nan
XPEHH/AOM.GWA/2/5 XPEHH Angola An. coluzzii 2R:27,980,000-28,040,000 96 95.2% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 38
    # data points      = 117
    # variables        = 4
    chi-square         = 9.847
    reduced chi-square = 0.087
    Akaike info crit   = -281.579
    Bayesian info crit = -270.530
[[Variables]]
    center:      0 (fixed)
    amplitude:   3.66107086 +/- 0.109631 (2.99%) (init= 3)
    sigma:       0.15543810 +/- 0.006633 (4.27%) (init= 0.5)
    skew:        0.50880130 +/- 0.049353 (9.70%) (init= 0)
    baseline:    1.18880096 +/- 0.031077 (2.61%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, sigma)          = -0.482
    C(sigma, skew)               = -0.307
    C(sigma, baseline)           = -0.236
    C(amplitude, baseline)       = -0.230

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 116
    # variables        = 1
    chi-square         = 129.105
    reduced chi-square = 1.123
    Akaike info crit   = 14.416
    Bayesian info crit = 17.170
[[Variables]]
    c:   1.65471269 +/- 0.098377 (5.95%) (init= 1)

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