XPEHH/GAS.GWA/X/1

This page describes a signal of selection found in the Gabon An. gambiae population when compared with the Guinea Bissau population using the XPEHH (Cite et al. 20XX) statistic.The focus of this signal is on chromosome arm X between positions 14,460,000 and 14,860,000. The evidence supporting this signal is moderate (\Delta_{i} >= 50 on both flanks).

Signal location. Blue markers show the values of the selection statistic. The dashed black line shows the fitted peak model. The shaded red area shows the focus of the selection signal. The shaded blue area shows the genomic region in linkage with the selection event. Use the mouse wheel or the controls at the top right of the plot to zoom in, and hover over genes to see gene names and descriptions.

Genes

The following 13 genes overlap the focal region: AGAP000795, AGAP000797 (E3 ubiquitin-protein ligase HECW2), AGAP0007982 (GLURIIc - ionotropic receptor GLURIIc), AGAP0008012 (GLURIIb - ionotropic receptor GLURIIb), AGAP0008032 (GLURIIa - ionotropic receptor GLURIIa), AGAP0008041 (GPXH2 - glutathione peroxidase 2), AGAP000805 (BTB/POZ domain-containing protein KCTD16), AGAP000806 (Angiopoietin-like 1), AGAP000807 (helix-loop-helix transcription factor), AGAP000808 (DNA damage-regulated autophagy modulator protein 2), AGAP013022, AGAP000809 (Proteasome 26S non-ATPase subunit 10), AGAP000810.

The following 6 genes are within 50 kbp of the focal region: AGAP000791 (Tango10), AGAP000792 (Adenosylhomocysteinase), AGAP000793, AGAP0007941 (NADH dehydrogenase (ubiquinone) Fe-S protein 2), AGAP013289, AGAP000812 (calcium binding protein).

Key to insecticide resistance candidate gene types: 1 metabolic; 2 target-site; 3 behavioural; 4 cuticular.

Overlapping selection signals

The following selection signals have a focus which overlaps with the focus of this signal.

Signal Statistic Population Focus Peak model \Delta_{i} Max. percentile Known locus
IHS/UGS/X/1 IHS Uganda An. gambiae X:14,640,000-15,360,000 517 96.7% Cyp9k1
IHS/BFM/X/1 IHS Burkina Faso An. coluzzii X:14,760,000-15,620,000 501 100.0% Cyp9k1
IHS/BFS/X/2 IHS Burkina Faso An. gambiae X:14,660,000-14,980,000 477 99.9% nan
H12/AOM/X/2 H12 Angola An. coluzzii X:14,500,000-14,600,000 243 96.4% nan
XPEHH/AOM.GWA/X/2 XPEHH Angola An. coluzzii X:14,500,000-15,180,000 228 98.5% nan

Diagnostics

The information below provides some diagnostics from the Peak modelling algorithm.

Selection signal in context. @@TODO

Peak targetting. @@TODO

Peak fitting diagnostics. @@TODO

Model fit reports

Peak model:

[[Model]]
    Model(skewed_gaussian)
[[Fit Statistics]]
    # function evals   = 57
    # data points      = 386
    # variables        = 4
    chi-square         = 87.094
    reduced chi-square = 0.228
    Akaike info crit   = -566.698
    Bayesian info crit = -550.874
[[Variables]]
    center:      0 (fixed)
    amplitude:   1.72267028 +/- 0.100249 (5.82%) (init= 3)
    sigma:       2.99999999 +/- 0.008305 (0.28%) (init= 0.5)
    skew:        0.78611878 +/- 0.052057 (6.62%) (init= 0)
    baseline:    1.00918523 +/- 0.097606 (9.67%) (init= 1)
    ceiling:     100 (fixed)
    floor:       0 (fixed)
[[Correlations]] (unreported correlations are <  0.100)
    C(amplitude, baseline)       = -0.908
    C(sigma, baseline)           =  0.809
    C(amplitude, sigma)          = -0.604
    C(sigma, skew)               =  0.380
    C(amplitude, skew)           = -0.331
    C(skew, baseline)            =  0.300

Null model:

[[Model]]
    Model(constant)
[[Fit Statistics]]
    # function evals   = 11
    # data points      = 385
    # variables        = 1
    chi-square         = 192.521
    reduced chi-square = 0.501
    Akaike info crit   = -264.821
    Bayesian info crit = -260.867
[[Variables]]
    c:   2.13708456 +/- 0.036086 (1.69%) (init= 1)

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